ABM: results of the competition for non-commercial clinical trials. Eight projects with a positive recommendation – Puls Medycyny

The chairman of the Medical Research Bureau approved the ranking of the results of the competition for non-commercial clinical trials after considering the protest. Eight of the sixteen projects were recommended for co-financing.

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Eight of the 16 applications submitted to the Medical Research Agency for non-commercial clinical trials received a positive opinion from the Agency’s president

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PLN 98 million is at stake

The chairman of the medical research bureau Radosław Sierpiński approved the ranking with the results of the competition for non-commercial clinical trials No. 2022 / ABM / 1. Applications submitted in the first round after treatment of the application have been taken into account protest from the substantive assessment.

Eight of the sixteen projects submitted were recommended for co-financing. The total amount of financial support is more than 98 million PLN.

Big winners

The Mother and Child Institute in Warsaw led the winners and received a total of 176 points. The least points were awarded to the Medical University of Lublin, whose project was at the very end.

We are talking about the project: Controlled, randomized, double-blind clinical trial evaluating changes in the gut microbiome and qualitative changes in the exome, qualitative/functional changes of transcriptome mRNA and microRNome-miRNA on neurocognitive and psychosocial functions of children with autism spectrum disorder (ASD) during the follow-up period and probiotic treatment of Lactobacillus rhamnosus. The agency did not award him any points and thus did not recommend this project.

The distinguished projects are:

  1. Institute for Mother and Child in Warsaw – Evaluation of the efficacy and safety of the use of naxitamab in patients with refractory Ewing sarcoma (BUTTERFLY), co-funded – PLN 14,447.952.90, 176 points
  2. Medical University of Gdansk – A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Levosimendan Therapy in Takotsubo Syndrome with Low Ejection Fraction (LevoTako Study), Grant – PLN 11 272 763.50, 165 points
  3. Jagiellonian University – Multicenter, controlled, randomized clinical trial comparing the effectiveness of auto- and allogeneic mesenchymal stromal cells in the healing of anal fistulas caused by Crohn’s disease, co-funded – PLN 12,554,850.00, 157 points
  4. Medical University of Warsaw – Evaluation of the efficacy and safety of extended-release budesonide in children with primary IgA nephropathy – multicenter, interventional phase III study, randomized, placebo-controlled, double-blind”, co-funded – PLN 12,152,836.00, 157 points
  5. National Institute of Geriatrics, Rheumatology and Rehabilitation prof. dr hab. med. Eleanor Reicher – Multicenter, randomized, double-blind clinical trial evaluating the efficacy and safety of etanercept compared to placebo in the treatment of patients with SAPHO syndrome, co-funded – PLN 12,192,647.68, 155 points
  6. National Oncology Institute Maria Skłodowskiej-Curie – National Research Institute – A Phase II single-arm study evaluating the efficacy and safety of pembrolizumab in combination with the LAG-3 agonist eftilagimod and radiotherapy in the preoperative treatment of patients with soft tissue sarcoma (EFTISARC-NEO), co-financed – PLN 7,214,791.28 , 155 points
  7. Medical University of Silesia – Interfant-21: International Joint Treatment Protocol for Infants Under One Year of Age with KMT2A Rearranged Acute Lymphocytic Leukemia or Mixed Phenotype Acute Leukemia, Grant – PLN 9,617,561.70, 150 points
  8. National Institute of Geriatrics, Rheumatology and Rehabilitation prof. dr hab. med. Eleanor Reicher – A multicenter clinical study evaluating the safety and efficacy of the combination of nintedanib and tocilizumab compared to standard therapy in patients with systemic sclerosis and interstitial lung disease. Analysis with the teranostic approach and evaluation of the activity of cytokines, markers of pneumonia and fibrosis using computed tomography, positron emission tomography and the study of the metabolome and transcriptome in selected patients. NINTOC-TU study, co-funding – PLN 18,637,156.76; 145 points.

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